Funded

Repeat protein Function Refinement, Annotation and Classification of Topologies

Excellence Hub on Phase Transitions in Aging and Age-Related Disorders

Driving the functional characterization of intrinsically disordered proteins

Connect and align ELIXIR Nodes to deliver sustainable FAIR life-science data management services

VHL syndrome (VHL) arises from pathogenic inactivation of the von Hippel-Lindau protein (pVHL). The pVHL mediates the degradation of HIF-1α transcription factor, thus regulating hypoxia response. In light of multiple types of cancer ascribed for VHL, different HIF-independent functions were attributed to pVHL. In particular it is thought to induce cell senescence, mediate assembly and…