Non-globular proteins (NGPs) encompass diverse molecular phenomena that challenge the traditional sequence-structure-function paradigm, including intrinsically disordered regions, tandem repeats, aggregating domains, low-complexity sequences, and transmembrane domains. While NGPs are implicated in numerous human diseases (neurodegenerative disorders, cancers, etc), progress in predicting and assessing mutations affecting non-globular regions has been hindered by the lack of a…