Expired
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DisProt 9.10 is now available
We are excited to announce the latest release of DisProt, featuring new curated annotations,continuous improvements to our curation workflow, and a new thematic dataset on stress-relatedproteins, highlighting the role of intrinsic disorder in cellular stress responses. Learn more about the new dataset and explore the disorder states and functions of these proteinsin our latest blog…
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Introducing the EOSC-ARENA Project
As part of the EOSC-ARENA (AI Research Enhancement through Networked Agents) consortium, BioComputing UP lab is pleased to announce the official launch of this three-year European Union-funded project, commenced on the 1st of June 2026. About the project EOSC-ARENA sets out to deliver a sovereign, generative and agentic Artificial Intelligence (AI) environment integrated with the…
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Open and sustainable AI: challenges, opportunities and the road ahead in the life sciences
Led by the BioComputing UP lab with broad participation from the ELIXIR Machine Learning Focus Group and involving experts from over 10 ELIXIR Nodes, a new perspective published in Nature Methods addresses the reproducibility, reusability and environmental crises in biological AI. The paper introduces 9 actionable recommendations for Open and Sustainable AI (OSAI) and provides…
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Highly Cited Researchers have demonstrated significant and broad influence in their field(s) of research
Each researcher selected has authored multiple Highly Cited Papers™ which rank in the top 1% by citations for their field(s) and publication year in the Web of Science™ over the past decade. However, citation activity is not the sole selection indicator. This list, based on citation activity is then refined using qualitative analysis and expert…
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Single-stranded DNA binding (SSB) protein-driven phase separation processes in cellular stress response
ABSTRACT: Bacterial single-stranded (ss)DNA-binding proteins (SSB) are essential for the replication and maintenance of the genome. SSBs share a conserved ssDNA-binding domain, a less conserved intrinsically disordered linker (IDL), and a highly conserved C-terminal peptide (CTP) motif that mediates a wide array of protein−protein interactions with DNA-metabolizing proteins. Here we show that the Escherichia coli SSB protein…
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Science4All: The Science Festival in Padua
In a 3 – hour marathon, live-streamed on YouTube, 20 scientists from the University of Padua will take turns on the festival stage to tell the general public about the challenges they have embraced and the scientific results they have achieved thanks to funding from the Ministry of University and Research with the PNRR Next…
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Career opportunity
The BiocomputingUP Group at the University of Padova seeks a motivated candidate who wants to contribute to cutting-edge biomedical research to investigate the role of phase separation in regulating pVHL physiological functions and its dysregulation in cancer progression.The successful candidate will be part of a dynamic and ambitious research group, lead by Prof. Silvio Tosatto and composed…
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Highly Cited Researchers 2024: eight are from the University of Padua
Highly Cited Researchers have demonstrated significant and broad influence in their field(s) of research Each researcher selected has authored multiple Highly Cited Papers™ which rank in the top 1% by citations for their field(s) and publication year in the Web of Science™ over the past decade. However, citation activity is not the sole selection indicator.…
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SHINING LIGHT ON FUNCTION AND STRUCTURE IN THE DARK PROTEIN UNIVERSE
ABSTRACT: Proteins, the drivers of machinery of cells and viruses, regulate their internal processes and interactions with the environment.Their shapes evolved to perform different roles across species, tightly linking structures to their functions. The collection of all proteins, known as the “Protein Universe” is vast and mostly unexplored, with few experimentally derived functions and structures.…