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Single-stranded DNA binding (SSB) protein-driven phase separation processes in cellular stress response
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ABSTRACT: Bacterial single-stranded (ss)DNA-binding proteins (SSB) are essential for the replication and maintenance of the genome. SSBs share a conserved ssDNA-binding domain, a less conserved intrinsically disordered linker (IDL), and a highly conserved C-terminal peptide (CTP) motif that mediates a wide array of protein−protein interactions with DNA-metabolizing proteins. Here we show that the Escherichia coli SSB protein…
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Science4All: The Science Festival in Padua
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In a 3 – hour marathon, live-streamed on YouTube, 20 scientists from the University of Padua will take turns on the festival stage to tell the general public about the challenges they have embraced and the scientific results they have achieved thanks to funding from the Ministry of University and Research with the PNRR Next…
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Career opportunity
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The BiocomputingUP Group at the University of Padova seeks a motivated candidate who wants to contribute to cutting-edge biomedical research to investigate the role of phase separation in regulating pVHL physiological functions and its dysregulation in cancer progression.The successful candidate will be part of a dynamic and ambitious research group, lead by Prof. Silvio Tosatto and composed…
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Highly Cited Researchers 2024: eight are from the University of Padua
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Highly Cited Researchers have demonstrated significant and broad influence in their field(s) of research Each researcher selected has authored multiple Highly Cited Papers™ which rank in the top 1% by citations for their field(s) and publication year in the Web of Science™ over the past decade. However, citation activity is not the sole selection indicator.…
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SHINING LIGHT ON FUNCTION AND STRUCTURE IN THE DARK PROTEIN UNIVERSE
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ABSTRACT: Proteins, the drivers of machinery of cells and viruses, regulate their internal processes and interactions with the environment.Their shapes evolved to perform different roles across species, tightly linking structures to their functions. The collection of all proteins, known as the “Protein Universe” is vast and mostly unexplored, with few experimentally derived functions and structures.…
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The Honorary Doctorate to Prof. Silvio Tosatto
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“For his scientific initiatives and the international relations he promoted, facilitating collaborations and exchange programs between the National University of Quilmes and various European institutions, primarily with the University of Padua, bringing benefits to many students and researchers, and strengthening the global reach of the academic activities of the National University of Quilmes.” With these…
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2024 Nobel prize in Chemistry to David Baker, Demis Hassabis and John Jumper
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The prestigious 2024 Nobel Prize in Chemistry has been awarded to three pioneers in the field of computational structural biology: David Baker, Demis Hassabis, and John Jumper. This recognition underscores the growing importance of artificial intelligence in life sciences. While Jumper and Hassabis are responsible for the AlphaFold project for the prediction of protein structures…
