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  • Targeting undruggable intrinsically disordered regions in childhood malignant neoplasms

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    We are dedicated to advancing the understanding of undruggable proteins and their role in cancer. Our research focuses on a specific category of proteins that lack stable drug-binding pockets, making them challenging to target effectively. In particular, we investigate intrinsically disordered proteins (IDPs) and regions (IDRs), which are characterized by their lack of a fixed…

  • von Hippel-Lindau (VHL) Tumor Suppressor

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    Inactivation of the VHL tumor suppressor gene is linked to the development of several different tumor types in humans, including hemangioblastomas of the retina and central nervous system, clear cell renal carcinoma, pancreatic cysts, pheochromocytoma. Biochemical studies revealed that pVHL interacts with several different proteins serving as a multipurpose adaptor protein that engages in multiple…

  • Cancer and Bioinformatics

    Cancer and Bioinformatics

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    Cancer is a complex and often devastating disease that arises from the uncontrolled growth and spread of abnormal cells in the body. As a multifactorial disease, cancer genesis is known to be influenced both by alteration of the genome and the environment. It can virtually affect any tissues of the body and is characterized by…

  • REFRACT

    REFRACT

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    Repeat protein Function Refinement, Annotation and Classification of Topologies

  • PhasAGE

    PhasAGE

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    Excellence Hub on Phase Transitions in Aging and Age-Related Disorders

  • IDPfun

    IDPfun

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    Driving the functional characterization of intrinsically disordered proteins

  • ELIXIR-CONVERGE

    ELIXIR-CONVERGE

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    Connect and align ELIXIR Nodes to deliver sustainable FAIR life-science data management services

  • Towards a mechanistic understanding of von Hippel-Lindau syndrome in different tissues

    Towards a mechanistic understanding of von Hippel-Lindau syndrome in different tissues

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    VHL syndrome (VHL) arises from pathogenic inactivation of the von Hippel-Lindau protein (pVHL). The pVHL mediates the degradation of HIF-1α transcription factor, thus regulating hypoxia response. In light of multiple types of cancer ascribed for VHL, different HIF-independent functions were attributed to pVHL. In particular it is thought to induce cell senescence, mediate assembly and…

  • Protein Function

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    Where we are actively engaged in the exciting field of function prediction for proteins. Our research in this area focuses on the development and implementation of advanced methodologies to predict Gene Ontology (GO) terms from protein sequences. One of our notable contributions is the INGA method, which leverages multiple sources of information to generate consensus…

  • Repeat Proteins

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    Tandem Repeat Proteins (TRPs) are proteins characterized by repetitive amino acid sequences, which have been the subject of extensive research for over two decades. Various authors have attributed distinct features related to sequence, structure, function, and evolution to these proteins. However, many prominent characteristics become apparent only when examining specific subclasses of tandem repeats. Our…