Abstract
Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene lead to VHL disease, characterized by vascular tumors like clear cell carcinoma, hemangioblastoma, and pheochromocytoma. pVHL is an adaptor protein implicated in many biological processes promoting cell survival. Phase separation (PS) has become increasingly significant in comprehending the regulation of multiple signaling pathways within cells, playing a role in controlling the spatial and temporal aspects of cellular signaling events. Its dynamic and integrative nature makes it a critical mechanism for orchestrating complex cellular responses to internal and external cues. pVHL has emerged as a widely recognized model system for investigating the physiological significance of stress induced aggregation in determining cell fate and fostering tumor development.
Funded by AIRC, the Italian Association for Cancer Research
