The BiocomputingUP Group at the University of Padova seeks a motivated candidate who wants to contribute to cutting-edge biomedical research to investigate the role of phase separation in regulating pVHL physiological functions and its dysregulation in cancer progression.
The successful candidate will be part of a dynamic and ambitious research group, lead by Prof. Silvio Tosatto and composed of three dozen people working on several aspects of protein structure & function prediction, employing techniques at the intersection between biology, medicine, chemistry, physics & computer science.

Qualifications:

• Master degree in Molecular Biology, Chemistry, Pharmaceutical Biotechnologies or related fields.
• Basic experience with molecular biology, cell biology and biochemistry.
• Good communication and teamwork skills

Key Responsibilities:

• Investigate the propensity of pVHL for phase separation and aggregation and identifying possible protein partners that promote this process. To assess the pH-dependent nucleolar detention of pVHL in diverse cancer cells specific for VHL-disease. To formulate a pharmacological strategy targeting aberrant pVHL PS to halt cancer.
• Using basic methodologies of molecular biology, such as DNA cloning, bacterial transformation, transfection, western blot, cell culture, cell viability, proliferation assay, colocalization assay, protein expression in prokaryotic and eukaryotic cells.
• Using tools, such as circular dichroism, electron microscope, fluorescent microscope.
• Preparing samples for Mass spectrometry.
• Collaborating closely with interdisciplinary teams at BioComputingUP.

Applicants are invited to submit their CV and a concise research/personal statement describing background/qualifications, future goals and reasons for the interest in this position. In addition, please include names and contact information of one (or more) professional reference. This position is available immediately, and applications will be accepted until the position is filled.

Contact Information: Prof. Giovanni Minervini or Dr. Emanuela Leonardi at biocomp@bio.unipd.it